Evaluation of Efficacy, Safety and Tolerability of a Combination of Clobetasol, Neomycin and Miconazole Versus Betamethasone, Clotrimazole and Neomycin Versus Betamethasone, Gentamycin and Miconazole in Subjects with Eczematous Disorders Associated with underlying Tinea or Yeast Infections.

Lobate GM Neo, 15 mg is a triple drug combination of a steroid clobetasol with anti-fungal miconazole and antibacterial neomycin in treatment of Eczematous disorders associated with underlying Tinea or Yeast Infections. Aims and Objectives: The study was designed to evaluate the efficacy, safety and tolerability of a combinations of clobetasol, neomycin and miconazole (Group A) versus betamethasone, clotrimazole, neomycin (Group B) versus betamethasone, gentamicin, miconazole (Group C) in subjects with any type of eczematous disorder associated with underlying tinea or yeast infection. Materials and Methods: This was an open label, parallel group, randomized comparative study. The primary endpoint analyzed was improvement in clinical score from baseline at the end of day 7 and other primary endpoint like hyperpigmentation were analyzed by the visual analogue scale of 1 to 10 at the end of day 7. Results: Thirty-six subjects were randomized to three groups. The clinical score showed a significant reduction from baseline at the end of day 7 in all the groups, i.e. 82.9%, 81.3% and 85.6% in Group A, B and C respectively. However, the difference between the groups were not statistically significant. Mean hyper pigmentation score showed significant decrease of 82.9% in Group A, 81.6% in Group B and 92.2% in Group C from baseline at the end of day 7. Conclusion: The triple combination of antifungal, antibacterial and potent steroid was found to be efficacious, safe and tolerable in reducing signs and symptoms (scaling, inflammation, burning and itching) of eczematous disorder associated with underlying tinea/yeast infection.

An Open, Comparative, Randomized, Parallel, Post Marketing, Multicentric Trial to Compare the Safety and Efficacy of Formula A (Ofloxacin + Ornidazole + Terbinafine Hydrochloride + Clobetasol Propionate) versus Formula B (Clotrimazole + Beclometasone Dipropionate + Neomycin Sulphate), Formula C (Clotrimazole + Beclometasone Dipropionate + Neomycin Sulphate) and Formula D (Clotrimazole + Beclometasone Dipropionate + Neomycin Sulphate) in the Treatment of Patients with Vaginitis.

Vaginitis is among the most common conditions for which women seek medical care, with vaginal discharge accounting for approximately 10 million office visits each year. Since there are no published studies till date that evaluated the Clinical Effectiveness and Safety of Topical Cream of Formula A [Ofloxacin (0.75 % w/w) + Ornidazole (2% w/w) + Terbinafine Hydrochloride (1% w/w) + Clobetasol Propionate (0.05% w/w)] compared to Formula B [Clotrimazole (1%w/w) + Beclometasone Dipropionate (0.025%w/w) + Neomycin Sulphate (0.5% w/w)], Formula C [Clotrimazole (1%w/w) + Beclometasone Dipropionate (0.025%w/w) + Neomycin Sulphate (0.5% w/w)], and Formula D [Clotrimazole (1%w/w) + Beclometasone Dipropionate (0.025%w/w) + Neomycin Sulphate (0.5% w/w)], in mild to moderate vaginitis, hence we undertook this randomized controlled Post Marketing Multicentric trial. Materials and methods: Female subjects diagnosed with mild to moderate symptoms of Vaginitis were eligible and those fulfilling the subject selection criteria were randomized to receive either Formula A, Formula B, Formula C or Formula D for 14 days. The Primary efficacy measures were assessment of symptoms of Vaginitis i.e. vaginal pruritis, vaginal irritation, vaginal soreness or pain, dyspareunia, vaginal erosion and vaginal inflammation and Secondary efficacy measures were assessment of Physical characteristics of vaginal discharge, assessment of pH of vaginal discharge and Microbiological evaluation. Assessment of Safety was done by recording the occurrence of adverse drug reactions. Results: The clinical success rates were comparable and even far better in case of Formula A group (in vaginal pain, Dyspareunia and vaginal erosion it was 100 %, in case of vaginal inflammation it was 92.655 % while in case of vaginal irritation, it was 94.767 % and vaginal pruritus, it was 87.096 %). Adverse events were mild and self limiting while it was totally absent in case of Formula A group. Conclusion: Topical Cream of Formula A is safe and effective for the treatment of mild to moderate vaginitis.

Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study.

The presented pilot study compared the effectiveness of combined antibiotic ophthalmic solution (neomycin sulfate, polymyxin B sulfate and gramicidin) with a placebo (artificial tear) in the treatment of hordeolum after incision and curettage (I&C). A randomized, placebo-controlled trial with patients and investigators blinded from the start started from June 2002 to May 2003. Subjects were patients with untreated hordeolum who subsequently underwent I&C at the Ophthalmology Department. The patients were randomized into 2 groups: group A for combined antibiotic ophthalmic solution, and group B for artificial tear containing the antibiotic solution base. Pain score, mass size and duration of cure were recorded before and on the 3rd and 7th day after treatment. The study included 14 patients in each group. Two subjects in group A and three subjects in group B dropped out. There were no statistically significant differences of all outcomes in both groups, even with the intention-to-treat analysis. The conclusion is combined antibiotic ophthalmic solution is not more effective than placebo in the treatment of hordeolum after I&C.

Antimicrobiano parenteral exclusivo ou associado com a via oral na prevenção de infecção após cirurgia colorretal / Prevention of the post-operative infection using parenteral antimicrobial agents alone or combined with oral administration

Estudo prospectivo da incidência de complicações infecciosas, após operações para câncer colorretal. Sessenta e nove pacientes foram divididos em dois grupos, tendo o primeiro grupo recebido neomicina e metronidazol, por via oral, associados a gentamicina e metronizadol por via parenteral e o segundo grupo somente gentamicina e metronidazol por via parenteral. Foi estabelecido como objetivo principal a avaliação da influência do antimicrobiano administrado no preparo intestinal sobre a incidência de complicações infecciosas pós-operatórias. Os pacientes que receberam antimicrobianos por via oral no preparo intestinal apresentaram menor porcentagem de complicações infecciosas (14,29 por cento) em relação aos pacientes que receberam apenas antimicrobiano por via parenteral (38,24 por cento), sendo esta diferença estatisticamente significante, em nível de 5 por cento. Esses dados apóiam a sugestão de associar antimicrobianos por via oral aos antimicrobianos por via parenteral na tentativa de reduzir as complicações infecciosas na cirurgia colorretal

Ileocecocistoplastia continente en niños con incontinencia irreversible / Continent ileocecocystoplasty in children with intractable urinary incontinence

En un estudio clínico, descriptivo y observacional, se analizaron la continencia urinaria, el impacto sobre la función renal y las complicaciones postoperatorias en niños operados de ileocecositoplastia continente en el servicio de Urología del Instituto Nacional de Pediatría, de agosto de 1992 a diciembre de 1993. Se analizaron las características clínicas más importantes al momento de la cirugía, el cuadro clínico, las pruebas de laboratorio y la continecia urinaria, preoperatoria y a los seis meses de la operación. También se analizaron, la longitud del segemento ileocecal utilizado y las complicaciones postoperatorias. Esta serie, que es la más numerosa descrita en niños, es de 13 pacientes entre tres y 17 años de edad, con alteración irreversible de la continencia urinaria. Las complicaciones postoperatorias fueron formación de cálculos en el reservorio en un caso, dehiscencia de la plicatura del ileon en otro y acidosis metabólica hiperclorémica en un caso. Consideramos que de las derivaciones urinarias continentes, la indicación más apropiada de la ileocecositoplastia es en niños con padecimiento congénitos que comprometen la continencia y cuya vejiga urinaria no necesita ser extirpada

Trasplante total heterotópico de intestino delgado en la rata: consideraciones técnicas para la obtención, preservación y trasplante del órgano / Total heterotype transplantation of the small intestine in rat:technical considerations about the obtention

Se comunica la técnica, modificaciones, y resultados, en el desarrollo experimental del transplante total heterotópico de intestino delgado en la rata. En el desarrollo del protocolo, se evaluaron todos los aspectos técnicos y de preservación, desde la descripción original de Monchik y Russell en 1917, sobre el trasplante total de intestino delgado en ratas, así como las modificaciones posteriores postuladas por diversos autores, y las de nuestro propio grupo. Se revisan los resultados obtenidos mediante el uso de modificaciones en la técnica de obtención y preservación del intestino delgado para el trasplante total heterotópico en la rata. Un total de 80 ratas sprague-dawley, fueron divididas en tres grupos (trasplante inmediato, con lavado del lecho vascular con solución salina, y trasplante a las 24 horas, con solución de lavado y preservación tipo UW y ADAAV) las supervivencia para cada uno de los grupos fue de 80, 50 y 70 por ciento respectivamente. Se discuten las ventajas de esta técnica, y su futuro uso para aspectos de investigación aplicables a la clínica del transplante de órganos

Effect of three antibacterial drugs in lowering blood & stool ammonia production in hepatic encephalopathy.

Neomycin (700 mg/8 h), ampicillin (500/6 h) and metronidazole (400 mg/8 h), were compared for their effect, on oral administration for 4 days, in reducing blood ammonia in 27 patients with stable chronic liver disease. It was found that there was 38.2, 38.5 and 8.7 m mol/litre mean reduction in blood ammonia in the neomycin, ampicillin and metronidazole treated groups respectively. The difference in blood ammonia was statistically significant for both neomycin (P = 0.01) and ampicillin (P = 0.03) but there was no significant change after metronidazole treatment (P = 0.6). The total stool enzyme activity at optimum pH was maximally reduced by ampicillin and minimally with metronidazole. The reduction was noted to be 3.51 m mol/1 (P = 0.01), 3.87 m mol/1 (P = 0.08) and 2.8 m mol/1 (P = 0.02) of NH3/g dry weight of stool for neomycin, ampicillin and metronidazole respectively. The main bacterial gut enzymes responsible for ammonia production, urease and protease, were found to be very sensitive to stool pH. At pH 6 their activity was around 20 per cent of what was found in optimum pH of 7.4 and at pH 5 it is only about 8 per cent of optimum activity. None of the three antibacterial agents changed the stool pH significantly. It can be concluded that oral neomycin and ampicillin are superior to oral metronidazole in lowering blood ammonia.

Tratamento local de uretrites inespecíficas e de cistites persistentes, com a soluçäo de neomicina a 1% e sulfametizol a 8% / Local treatment of unspecific urethritis and persistent cystitis with 1% neomicina solution and an 8% sulfametizol solution

O Autor estudou o emprego da terapêutica local das infecçöes urinárias baixas, em esquema de curto prazo, através da instilaçäo uretral e/ou vesical de uma soluçäo de neomicina a 1% e sulfametizol a 8%, pronta para uso. Para tanto, utilizou dois grupos de pacientes: Grupo I, de 20 homens entre 18 e 42 anos de idade, com uretrite inespecífica e Grupo II, de 5 homens entre 24 e 70 anos e 15 mulheres entre 18 e 65 anos, portadores de uretro-trigonites persistentes. Os pacientes dos dois grupos receberam a medicaçäo tópica, ainda que a uma parte deles tivesse sido permitida uma terapêutica concomitante, de patologias associadas, que näo interferisse na avaliaçäo dos resultados do tratamento local. Utilizaram-se critérios diagnósticos e do controle clínico e laboratorial para proceder-se à avaliaçäo da eficácia e tolerabilidade ao tratamento local. O produto mostrou-se eficaz nos portadores de uretrite inespecífica do Grupo I bem como nos casos de cistite crônica do Grupo II. Quanto à tolerabilidade, foi 100% Boa no Grupo II e de 95% Boa no Grupo I, no qual houve um abandono de tratamento por intolerância à medicaçäo. conclui o autor que os resultados obtidos como emprego de uma instilaçäo diária da soluçäo de neomicina a 1% e sulfametizol a 8%, durante 5 dias em média, foram comprobatórios da reduçäo e do desaparecimento dos sintomas/sinais predominantes nas infecçöes das vias urinárias inferiores, eliminando os germes em elevada porcentagem dos casos